![]() ![]() Conclusions: The concurrence of modifications in plasma leptin and thyroid hormones concentrations found in elderly NTI patients with a sick euthyroid syndrome could reflect a particular neuroendocrine status, leading to a reduction in the catabolic processes in the course of chronic diseases. Euthyroid sick syndrome ( ESS) is a state of adaptation or dysregulation of thyrotropic feedback control 1 wherein the levels of T3 and/or T4 are abnormal, but the thyroid gland does not appear to be dysfunctional. Moreover, plasma leptin concentrations were directly correlated to BMI in all the groups studied, while a negative correlation between leptin and rT 3 was detectable in group C (r = –0.44, p < 0.05), also after adjusting for BMI and sex. ![]() Females also showed higher plasma leptin levels than males in the controls, group A and group B, but not in group C. The patients of group C showed lower plasma leptin levels than the controls, 6.6 (5.5–14.2) and 16.3 (7.2–23.7) ng/ml (median with interquartile range in parentheses, p < 0.05), respectively. THE TERM euthyroid sick syndrome (ESS) identifies abnormalities in thyroid function tests observed in patients with systemic nonthyroidal illnesses (NTIs) and. Results: The data on thyroid hormones enabled us to identify three groups: group A, subjects (15 patients) with T 3 and fT 3 levels comparable to those of controls group B, subjects (25 patients) with T 3 and fT 3 levels lower than controls and rT 3 levels comparable to those of controls group C, subjects (24 patients) with T 3 and fT 3 levels lower than those of controls and high rT 3 levels. Nutritional status was also evaluated in all subjects studied by the measurement of body mass index (BMI), lymphocytes, serum iron, hemoglobin, plasma albumin, transferrin and total cholesterol. Euthyroid sick syndrome (ESS) refers to abnormal thyroid levels resulting from an acute illness in a patient with no preexisting or current dysfunction in the thyroid gland. ![]() In all subjects tri-iodothyronine (T 3), thyroxine (T 4), reverse T 3 (rT 3), free T 3 (fT 3), free T 4 (fT 4), TSH, and plasma leptin concentrations were measured. patients were thought to be euthyroid, and the term ' euthyroid sick syndrome ' was used to describe the laboratory abnormalities. Methods: Sixty-four NTI elderly patients (75.0 ± 6.3 years, 27 males and 37 females) and 21 age- and sex-matched healthy controls (73.0 ± 5.5 years, 9 males and 12 females) were enrolled in the study. Objective: To evaluate plasma leptin concentrations and thyroid function in elderly patients with nonthyroidal illnesses (NTI). Euthyroid sick syndrome is not a thyroid disorder but instead is a group of changes in serum TSH and thyroid hormones and tissue thyroid hormone levels that result from cytokines and inflammatory mediators produced in patients with nonthyroidal illnesses. Background: Leptin, the ob gene product, seems to be involved in regulating energy expenditure in humans, but its role in the pathophysiology of the energy imbalance in chronically ill patients is largely unknown. Euthyroid Sick Syndrome In this review, we discuss the characteristics, pathophysiology, and therapeutic implications of the euthyroid sick syndrome. ![]()
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